Home Page

I am following several blogs that discuss the latest longevity research, but I didn’t see anything there since the release of the product.

Any new studies or developments to report on this product? I recently purchased it and wish to know if the One Skin researchers published their results in a peer-reviewed journal yet, or if more results have been discovered.

Yeah, that was the idea when Yamanaka found those four transcription factors. He didn’t even think of using them for rejuvenation. But later it turned out that rejuvenation and inducing stemness are two different processes. This makes sense because both processes are probably relatively complex and different enzymes are needed to get the job done. The Yamanaka factors trigger a cascade of events and once we understand the details of these processes it might be possible to control the rejuvenation part more reliably without risking turning differentiated cells into stem cells.

Ok, thanks again…I just had gotten the impression, from the MIT piece, that cell reprogramming by definition turns the cell into a stem cell, but in fact you pointed out that they’ve avoided doing this, so it seemed like they missed that very-important point. But I guess writing popular articles for new science can be a challenge to please all people 🙂

I’m mostly excited about Altos but I know popular science articles about Aging in particular are not normally looked-upon as helpful by those same scientists necessarily, for various reasons (like hype, or snake-oil, eternal dictators, sisyphus, etc).

hplus:

Obviously, you can’t just turn specialized cells into stem cells in a living organism. If you turn a heart cell into a stem cell, it can no longer do its job in the heart and instead will cause cancer. However, Sinclair believes that it is possible to avoid this problem by working with a subset of the Yamanaka factors (without c-Myc) and by limiting the reprogramming time.

So I discussed the exact same problem. Sinclair and Belmonte proved that it can be done in vivo. But Ocampo is certainly right when he says that it is a risky procedure and it remains to be seen if this technology can be used in humans. So no contraction.

OK sure.
MIT: “One problem is that reprogramming doesn’t just make cells act younger but also changes their identity—for instance, turning a skin cell into a stem cell. That is what makes the technology too dangerous to try on people yet.”

hplus: “To start the rejuvenation process, doxycycline is given for a certain time. This activates the combination of the Yamanaka factors, which reverses the age of all cells without turning them into stem cells. After this, the treatment with doxycycline is discontinued.”

the issue is whether reprogramming changes the identity of cells–that seems to me to be the contradiction…

happy to hear your feedback, thank you much!
Eugene

Please formulate your argument here. In what way does my article contradict this paper?

If you look at my tweet I point it out w/2 pics

I read the article, but didn’t have the time yet to read the preprint paper. Where do you see a contradiction?

Mike, I just tweeted about your article, and how it seems to contradict the latest big story in MIT Tech Review about Altos Labs…

@davidasinclair @realNathanCheng @jpsenescence

Did MIT Tech Review re: Altos Labs basically print a non-factual statement below, which seems *pretty important* to get wrong?

sources:https://t.co/Njkcap4hD8https://t.co/SuvVBBj8Pa pic.twitter.com/6BHiJIKucy

— Euge (@eugediana) September 6, 2021

please correct me if I’m wrong I’d really appreciate it…
Eugene