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Michael Pietroforte commented on Diamandis and OneSkin OS-01: Reverse the biological age of your skin by clearing senescent cells 2 years, 2 months ago
I am following several blogs that discuss the latest longevity research, but I didn’t see anything there since the release of the product.
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Marissa commented on Diamandis and OneSkin OS-01: Reverse the biological age of your skin by clearing senescent cells 2 years, 2 months ago
Any new studies or developments to report on this product? I recently purchased it and wish to know if the One Skin researchers published their results in a peer-reviewed journal yet, or if more results have been discovered.
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Michael Pietroforte commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 8 months ago
Yeah, that was the idea when Yamanaka found those four transcription factors. He didn’t even think of using them for rejuvenation. But later it turned out that rejuvenation and inducing stemness are two different processes. This makes sense because both processes are probably relatively complex and different enzymes are needed to get the job done. The Yamanaka factors trigger a cascade of events and once we understand the details of these processes it might be possible to control the rejuvenation part more reliably without risking turning differentiated cells into stem cells.
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Eugene commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 8 months ago
Ok, thanks again…I just had gotten the impression, from the MIT piece, that cell reprogramming by definition turns the cell into a stem cell, but in fact you pointed out that they’ve avoided doing this, so it seemed like they missed that very-important point. But I guess writing popular articles for new science can be a challenge to please all people 🙂
I’m mostly excited about Altos but I know popular science articles about Aging in particular are not normally looked-upon as helpful by those same scientists necessarily, for various reasons (like hype, or snake-oil, eternal dictators, sisyphus, etc).
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Michael Pietroforte commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 8 months ago
hplus:
Obviously, you can’t just turn specialized cells into stem cells in a living organism. If you turn a heart cell into a stem cell, it can no longer do its job in the heart and instead will cause cancer. However, Sinclair believes that it is possible to avoid this problem by working with a subset of the Yamanaka factors (without c-Myc) and by limiting the reprogramming time.
So I discussed the exact same problem. Sinclair and Belmonte proved that it can be done in vivo. But Ocampo is certainly right when he says that it is a risky procedure and it remains to be seen if this technology can be used in humans. So no contraction.
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Eugene commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 8 months ago
OK sure.
MIT: “One problem is that reprogramming doesn’t just make cells act younger but also changes their identity—for instance, turning a skin cell into a stem cell. That is what makes the technology too dangerous to try on people yet.”hplus: “To start the rejuvenation process, doxycycline is given for a certain time. This activates the combination of the Yamanaka factors, which reverses the age of all cells without turning them into stem cells. After this, the treatment with doxycycline is discontinued.”
the issue is whether reprogramming changes the identity of cells–that seems to me to be the contradiction…
happy to hear your feedback, thank you much!
Eugene -
Michael Pietroforte commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 8 months ago
Please formulate your argument here. In what way does my article contradict this paper?
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Eugene commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 8 months ago
If you look at my tweet I point it out w/2 pics
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Michael Pietroforte commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 8 months ago
I read the article, but didn’t have the time yet to read the preprint paper. Where do you see a contradiction?
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Eugene commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 8 months ago
Mike, I just tweeted about your article, and how it seems to contradict the latest big story in MIT Tech Review about Altos Labs…
@davidasinclair @realNathanCheng @jpsenescence
Did MIT Tech Review re: Altos Labs basically print a non-factual statement below, which seems *pretty important* to get wrong?
sources:https://t.co/Njkcap4hD8https://t.co/SuvVBBj8Pa pic.twitter.com/6BHiJIKucy
— Euge (@eugediana) September 6, 2021
please correct me if I’m wrong I’d really appreciate it…
Eugene -
Michael Pietroforte commented on Mind uploading and consciousness – Why an uploaded mind will be unconscious 2 years, 9 months ago
The point is that representing a physical property (intrinsic or systemic) is not enough to recreate this property physically. Representing a physical property in a book does not recreate this property. A book about black holes does not create black holes. Nobody who is reading a book about black holes has to fear to be swallowed by the book.
I am fine with different types of consciousness and an artificial brain that consists of physical neurons made of silicon might be conscious. We will know for sure once we have a theory of consciousness. However at this point we don’t have a clue how this theory could look like. It is futile to try to build something that we don’t understand at all.
What we already know for sure is that simulating neurons on a computer will not recreate physical neurons and therefore also not recreate consciousness just as simulating black holes on a computer does not recreate real, physical gravity. Nobody will be drawn into a computer by simulating black holes. Representations don’t have the physical powers of the things they represent. They only represent these physical powers.
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Michael commented on Mind uploading and consciousness – Why an uploaded mind will be unconscious 2 years, 9 months ago
at what point does a intrinsic property being accurately represented lose any meaning ? a artificial brain does not have to be conscious in the exact we are. it only has to be close enough that it is functionally the same. you cant honestly expect that them to have to be one to one. you don’t need a perfect water simulation. you just need a accurate one.
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Michael Pietroforte commented on How and when mother nature resets the aging clock and why the wear and tear theory of aging is worn out 2 years, 9 months ago
Then why did he die if he invented the immortal tea? 😉
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Moses commented on How and when mother nature resets the aging clock and why the wear and tear theory of aging is worn out 2 years, 9 months ago
There was a lebanese who invented the immortal tea to defy death. He died at 127 had a 7 years old biologic son. Also invented some body movements.
[email protected] -
Michael Pietroforte wrote a new post 2 years, 9 months ago
A new study found that according to an rDNA clock the biological age is reset in mouse embryos approximately 4.5 to 10.5 days after fertilization. In my view, this is further empirical proof that the wear and tear of aging is essentially wrong.
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Michael Pietroforte commented on A summary of David Sinclair’s Information Theory of Aging 2 years, 9 months ago
Conrad, thanks! The thing with the lost Sir2 is in the book. For example, on p. 47:
It’s not so much that the sirtuins are overwhelmed, though they probably are when you are sunburned or get an X-ray; what’s happening every day is that the sirtuins and their coworkers that control the epigenome don’t always find their way back to their original gene stations after they are called away.
Sinclair, David . Lifespan: Why We Age—and Why We Don’t Have To (p. 47). Atria Books. Kindle Edition.
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I found this post the same way as Pedro – I am glad I wasn’t the only one who didn’t understand Sinclair’s “Magna superstes” example!
Michael, can I ask where you got the Sir-2 getting “lost” detail from? This causes the explanation to make so much more sense, but I just double checked and it is definitely not mentioned in Sinclair’s explanation or the accompanying diagram. -
Michael Pietroforte commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 11 months ago
I don’t think that the average age of death matters. As long as there are some individuals that are not killed by predators, it would makes sense that they keep reproducing until they are killed.
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Ricardo commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 11 months ago
What large number? If life expectancy was around 30y that’s the average age of death. I haven’t found a model of the distribution but I’d expect very few to reach more than 50 years. Moreover it’s not clear early humans could afford to have multiple sequential children. If you have a child at 30 you need to survive until 45 to help it reach adulthood, otherwise it’s useless, and maybe that nearly never happened. Sexual selection could also come into play with humans favoring younger.
Though I’ve read the other post about aging being programmed to ensure innovation and it does make sense.
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Michael Pietroforte commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 2 years, 11 months ago
I heard this argument many times and I find it very implausible. What about the large number of organisms that are not killed by predators? Why wouldn’t evolution make sure that they continue reproducing until they are eventually killed?
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