In the video at the end of the text, Ray Kurzweil discusses the idea of connecting our brains to...
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Michael Pietroforte wrote a new post, David Sinclair’s level 3: Reversing aging with the Yamanaka factors 4 weeks ago
In my last post, I outlined David Sinclair’s anti-aging levels 1 and 2. Whereas levels 1 and 2 can, at best, slow the aging process, level 3 has the potential to provide a real cure for aging. At level 3, at least in theory, we can completely reverse the age…
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Nice! I know Aubrey but I have never read about his theory in detail, only very superficially. I agree that the Yamanaka factors seem to be the most promising ones. They are also the most exciting ones, the idea of reversing aging is just amazing! I’m not old, I’m 27,…
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Michael Pietroforte commented on A summary of David Sinclair’s Information Theory of Aging 1 month, 2 weeks ago
I think what he says about stress is consistent. Stress causes damage which causes aging. Moderate stress makes cells hunker down and focus on repairing damage. Thus, moderate stress slows aging, too much stress accelerates aging. Where I can’t follow is his claim that energy costs prevent cells from repairing…
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Yeah, I’m reading the book and I didn’t understand his argument in the beginning. This is why I looked for an explanation and found your website. It seems a little contradictory indeed because it is not the damage itself that causes aging but the lack of sirtuins in the epigenome.…
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Michael Pietroforte commented on A summary of David Sinclair’s Information Theory of Aging 1 month, 2 weeks ago
I don’t understand where you see a contradiction in my argument. It goes like this: If Sir2 doesn’t find its way back, the cell can no longer replicate. Building an extra Sir2 that replaces the missing one would allow the cell to replicate again. But Sinclair claims that building an…
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Michael Pietroforte commented on A summary of David Sinclair’s Information Theory of Aging 1 month, 2 weeks ago
There are only a couple of scientists doing research with sirtuins in yeast and I doubt that they have interest in disproving Sinclair’s claim about the energy costs. The argument about the conditions in primordial times is not valid because if building more Sir2 would bring and evolutionary advantage, yeast…
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Yes, I agree with you. There should be experiments to test if the energy cost is the same or if it is higher. If it is the same, then the theory is in trouble. If it is a little higher then I believe the theory still stands, considering that primordial…
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“First, why don’t cells simply make more repair enzymes? For instances, if Sir2 doesn’t sometimes find its way back to its original position, why not simply make more Sir2? In fact, Sinclair has shown that adding an extra copy of SIR2 increases the lifespan (the number of divisions) in yeast…
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Michael Pietroforte's profile was updated 2 months, 4 weeks ago
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Michael Pietroforte wrote a new post, Why we don't have to age: A short discussion of David Sinclair's anti-aging level 1 and 2 2 months, 4 weeks ago
In my last post, I outlined David Sinclair’s information theory of aging which claims to explain why we age. Today, I will summarize why Sinclair thinks that we don’t have to accept this unfortunate fate. Essentially, Sinclair claims that we can intervene in the aging process at three different levels:…
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