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Eugene commented on David Sinclair’s level 3: Reversing aging with the Yamanaka factors 1 day, 2 hours ago
Terrific article
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Michael Pietroforte wrote a new post, Book review of Jean Hebert's "Replacing Aging," part 1: Why gerontology is not the solution 2 weeks, 5 days ago
The title of Jean M. Hébert’s recently published book, Replacing Aging, fits the book nicely. Another title that would fit even better (but wouldn’t sound so appealing) would be “Replacing Anti-aging Research.” In the first part, Professor Hébert of the Albert Einstein College of Medicine essentially dismantles all major approaches…
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Michael Pietroforte wrote a new post, Diamandis and OneSkin OS-01: Reverse the biological age of your skin by clearing senescent cells 2 months, 1 week ago
Peter Diamandis has pitched the new product of OneSkin Technologies, a company that claims to be able to reverse the biological age of your skin by clearing senescent cells. In this post, I summarize the science behind this new approach to skin anti-aging.
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Michael Pietroforte wrote a new post, David Sinclair’s level 3: Reversing aging with the Yamanaka factors 4 months, 2 weeks ago
In my last post, I outlined David Sinclair’s anti-aging levels 1 and 2. Whereas levels 1 and 2 can, at best, slow the aging process, level 3 has the potential to provide a real cure for aging. At level 3, at least in theory, we can completely reverse the age…
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Nice! I know Aubrey but I have never read about his theory in detail, only very superficially. I agree that the Yamanaka factors seem to be the most promising ones. They are also the most exciting ones, the idea of reversing aging is just amazing! I’m not old, I’m 27,…
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Michael Pietroforte commented on A summary of David Sinclair’s Information Theory of Aging 5 months, 1 week ago
I think what he says about stress is consistent. Stress causes damage which causes aging. Moderate stress makes cells hunker down and focus on repairing damage. Thus, moderate stress slows aging, too much stress accelerates aging. Where I can’t follow is his claim that energy costs prevent cells from repairing…
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Yeah, I’m reading the book and I didn’t understand his argument in the beginning. This is why I looked for an explanation and found your website. It seems a little contradictory indeed because it is not the damage itself that causes aging but the lack of sirtuins in the epigenome.…
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Michael Pietroforte commented on A summary of David Sinclair’s Information Theory of Aging 5 months, 1 week ago
I don’t understand where you see a contradiction in my argument. It goes like this: If Sir2 doesn’t find its way back, the cell can no longer replicate. Building an extra Sir2 that replaces the missing one would allow the cell to replicate again. But Sinclair claims that building an…
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Michael Pietroforte commented on A summary of David Sinclair’s Information Theory of Aging 5 months, 1 week ago
There are only a couple of scientists doing research with sirtuins in yeast and I doubt that they have interest in disproving Sinclair’s claim about the energy costs. The argument about the conditions in primordial times is not valid because if building more Sir2 would bring and evolutionary advantage, yeast…
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Yes, I agree with you. There should be experiments to test if the energy cost is the same or if it is higher. If it is the same, then the theory is in trouble. If it is a little higher then I believe the theory still stands, considering that primordial…
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