Author Archive for: Michael Pietroforte

Nice! I know Aubrey but I have never read about his theory in detail, only very superficially. I agree that the Yamanaka factors seem to be the most promising ones. They are also the most exciting ones, the idea of reversing aging is just amazing! I’m not old, I’m 27,…

I think what he says about stress is consistent. Stress causes damage which causes aging. Moderate stress makes cells hunker down and focus on repairing damage. Thus, moderate stress slows aging, too much stress accelerates aging. Where I can’t follow is his claim that energy costs prevent cells from repairing…

Yeah, I’m reading the book and I didn’t understand his argument in the beginning. This is why I looked for an explanation and found your website. It seems a little contradictory indeed because it is not the damage itself that causes aging but the lack of sirtuins in the epigenome.…

I don’t understand where you see a contradiction in my argument. It goes like this: If Sir2 doesn’t find its way back, the cell can no longer replicate. Building an extra Sir2 that replaces the missing one would allow the cell to replicate again. But Sinclair claims that building an…

There are only a couple of scientists doing research with sirtuins in yeast and I doubt that they have interest in disproving Sinclair’s claim about the energy costs. The argument about the conditions in primordial times is not valid because if building more Sir2 would bring and evolutionary advantage, yeast…

Yes, I agree with you. There should be experiments to test if the energy cost is the same or if it is higher. If it is the same, then the theory is in trouble. If it is a little higher then I believe the theory still stands, considering that primordial…

“First, why don’t cells simply make more repair enzymes? For instances, if Sir2 doesn’t sometimes find its way back to its original position, why not simply make more Sir2? In fact, Sinclair has shown that adding an extra copy of SIR2 increases the lifespan (the number of divisions) in yeast…